alpha-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for alpha-synuclein aggregates and can inhibit alpha-synuclein aggregation. alpha-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit alpha-synuclein fibril formation by blocking the aggregation process. alpha-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. alpha-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinsons disease and Lewy body dementia[1][2].
