TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206+ and CX3CR1+ immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells[1].
Molekulargewicht:
1164.12
Reinheit:
99.34
CAS Nummer:
[2000236-36-0]
Formel:
C46H68N2O20Pt
Target-Kategorie:
Apoptosis
Anwendungsbeschreibung:
Reference compound
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