IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC50 values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia[1].
Molekulargewicht:
976.22
Reinheit:
98.53
Formel:
C54H57N9O5S2
Target-Kategorie:
Epigenetic Reader Domain,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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