Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 µM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model[1].
Molekulargewicht:
247.23
Reinheit:
97.65
CAS Nummer:
[1223877-07-3]
Formel:
C11H10FN5O
Target-Kategorie:
Phosphatase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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