PARP/EZH2-IN-2 (compound 12e) is a dual target PARP1 and EZH2 inhibitor, with IC50 values of 6.89 and 27.34 nM, respectively. PARP/EZH2-IN-2 shows anticancer activity, with no toxicity to normal cells. PARP/EZH2-IN-2 achieves synthetic lethality indirectly by inhibiting EZH2 to increase the sensitivity to PARP1, and induces cell death by regulating excessive autophagy[1].
Molekulargewicht:
573.64
Formel:
C33H31N7O3
Target-Kategorie:
Histone Methyltransferase,PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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