Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC50 of 0.07 µM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K+, Na+, and Ca2+ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H2O2. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke[1].
Molekulargewicht:
383.48
Reinheit:
98.64
CAS Nummer:
[2252448-93-2]
Formel:
C22H29N3O3
Target-Kategorie:
Apoptosis,Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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