BI-4732, CAS [[2769715-68-4]]

Produktübersicht

• Artikelname: BI-4732, CAS [[2769715-68-4]]
• Artikelnummer: MCE-HY-161275
• Hersteller Artikelnummer: HY-161275
• Alternativnummer: MCE-HY-161275-100MG,MCE-HY-161275-25MG,MCE-HY-161275-10MG,MCE-HY-161275-50MG,MCE-HY-161275-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

BI-4732 is an orally active, reversible, ATP-competitive EGFR inhibitor with blood-brain barrier penetration. BI-4732 inhibits the kinase activity of EGFR L858R, T790M and C797S with IC50 values of 1 nM while sparing EGFR wild-type. BI-4732 inhibits EGFR and reduces the phosphorylation of AKT, ERK, and S6K. BI-4732 demonstrates excellent intracranial anti-tumor efficacy in YU-1097 xenograft model harboring EGFR_E19del/T790M/C797S. BI-4732 can be used for the study of non-small cell lung cancer (NSCLC)[1].

Produkteigenschaften

• Molekulargewicht: 592.69
• Reinheit: 99.30
• CAS Nummer: [2769715-68-4]
• Formel: C32H36N10O2
• Target-Kategorie: Akt,EGFR,ERK,Ribosomal S6 Kinase (RSK)

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound