ITF5924 (compound 1) is a potent and highly selective HDAC6 inhibitor with an IC50 of 7.7 nM. ITF5924 shows greater than 104-fold selectivity for HDAC6 over all other HDAC subtypes. ITF5924 containing a difluoromethyl-1,3,4-oxadiazole (DFMO) moiety is slow-binding substrate analog of HDAC6 that undergo an enzyme-catalyzed ring opening reaction, forming a tight and long-lived enzyme-inhibitor complex[1].
Molekulargewicht:
436.42
CAS Nummer:
[2760854-72-4]
Formel:
C21H18F2N8O
Target-Kategorie:
HDAC
Anwendungsbeschreibung:
Reference compound
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