NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IkappaBalpha and NF-kappaB/p65 and the nuclear translocation of p65, thereby inhibiting NF-kappaB signaling[1].
Molekulargewicht:
412.32
Formel:
C21H22BrN3O
Target-Kategorie:
IKK,NF-kappaB,NOD-like Receptor (NLR),Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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