WH244 is a second generation BCL-2 and BCL-xL dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of BCL-2 and BCL-xL proteins (BCL-xL: DC50=0.6 nM, BCL-2: DC50=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cells apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415), Blue: E3 ligase ligand (HY-112078), Black: linker)[1].
Molekulargewicht:
1681.51
Reinheit:
99.82
CAS Nummer:
[2941088-96-4]
Formel:
C83H105ClF3N13O11S4
Target-Kategorie:
Apoptosis,Bcl-2 Family,PROTACs
Anwendungsbeschreibung:
Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
