S21-1011 is a selective inhibitor for butyrylcholinesterase (BChE), with IC50 of 0.059 and 0.162 µM, for eqBChE and hBChE, respectively. S21-1011 exhibits good blood-brain barrier (BBB) permeability and good pharmacokinetic characters. S21-1011 exhibits anti-inflammatory activity through activation of keap1-Nrf2-ARE pathway (EC50 is 23.48 µM for antioxidant element ARE activation), ameliorates cognitive impairment in murine Alzheimers disease model[1].
Molekulargewicht:
464.60
CAS Nummer:
[2671859-87-1]
Formel:
C30H32N4O
Target-Kategorie:
Cholinesterase (ChE),Keap1-Nrf2
Anwendungsbeschreibung:
MCE Product type: Reference compound
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