PROTAC SOS1 degrader-10, CAS [[3043923-74-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC SOS1 degrader-10, CAS [[3043923-74-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-161654
• Hersteller Artikelnummer: HY-161654
• Alternativnummer: MCE-HY-161654-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC SOS1 degrader-10 (Compound 11o) is a degrader for son of sevenless 1 (SOS1) in a CRBN and proteasome dependent manner. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS mutant cancer cells SW620, A549 and DLD-1, with DC50s of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits the proliferations of cells SW620, A549 and DLD-1, with IC50s of 36.7, 52.2 and 107 nM, respectively. PROTAC SOS1 degrader-10 inhibits phosphorylation of ERK. (Pink: SOS1 ligand (HY-161655), Black: linker (HY-161656), Blue: E3 ligase ligand (HY-W249500))[1]

Produkteigenschaften

• Molekulargewicht: 969.10
• CAS Nummer: [3043923-74-3]
• Formel: C51H63F3N10O6
• Target-Kategorie: PROTACs,Ras,SOS1

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound