GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC50 of 0.83 µM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC90 of 3.5 µM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC90 of 1.96-7.79 µM. (Pink: ligand for target protein (HY-161805), Black: linker (HY-42149), Blue: ligand for E3 ligase (HY-23095))[1]
Molekulargewicht:
762.69
Formel:
C37H33F3N6O9
Target-Kategorie:
Dengue Virus,PROTACs
Anwendungsbeschreibung:
Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
