Tubulin polymerization-IN-67 Preis auf Anfrage

Produktübersicht

• Artikelname: Tubulin polymerization-IN-67 Preis auf Anfrage
• Artikelnummer: MCE-HY-161863
• Hersteller Artikelnummer: HY-161863
• Alternativnummer: MCE-HY-161863-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Tubulin polymerization-IN-67 (Compound 5h) is an inhibitor for tubulin polymerization on colchicine binding site with an IC50 of 2.92 µM. Tubulin polymerization-IN-67 inhibits the proliferation of cancer cells HT29, A549, U2OS, MG-63 and HeLa with IC50s of 0.12-4.13 µM. Tubulin polymerization-IN-67 arrests the cell cycle at G2/M phase, induces apoptosis in cell U2OS, inhibits the cell migration of A549. Tubulin polymerization-IN-67 reduces the mitochondrial membrane potential (MMP) and increase intracellular ROS, inhibits the angiogenesis in HUVECs. Tubulin polymerization-IN-67 exhibits antitumor efficacy in mice[1]

Produkteigenschaften

• Molekulargewicht: 422.47
• Formel: C24H26N2O5
• Target-Kategorie: Apoptosis,Microtubule/Tubulin,Reactive Oxygen Species (ROS)

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound