Top1/2-IN-1 (compound 23) is an orally available dual inhibitor of Top1/2 with antiproliferative activity. Top1/2-IN-1 damages DNA with increased levels of reactive oxygen species, inducing apoptosis and cell cycle arrest in cancer cells. Top1/2-IN-1 exhibits in vivo antitumor activity in xenograft models[1].
Molekulargewicht:
347.41
Formel:
C21H21N3O2
Target-Kategorie:
Topoisomerase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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