NSD-IN-3 (compound 3) is a potent nuclear receptor binding SET domain (NSD) inhibitor. NSD-IN-3 inhibits NSD2-SET and NSD3-SET with IC50 values of 0.81 µM and 0.84 µM, respectively. NSD-IN-3 inhibits histone H3K36 dimethylation and decreases the expression of NSDs-targeted genes in non-small cell lung cancer cells. NSD-IN-3 induces s-phase cell cycle arrest and apoptosis[1].
Molekulargewicht:
334.17
Reinheit:
98
CAS Nummer:
[744260-15-9]
Formel:
C13H12BrN5O
Target-Kategorie:
Apoptosis,Histone Methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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