LDR102 (Compound 19h) is an inhibitor for receptor tyrosine kinase-like orphan receptor 1 (ROR 1) with Ki of 0.10 µM. LDR102 inhibits proliferation of cancer cells H1975, A549 and MDA-MB-231, with IC50 of 0.36 µM, 1.37 µM and 0.47 µM. LDR102 exhibits antitumor efficacy in mice and good pharmacokinetic characteristics in rat models[1].
Molekulargewicht:
541.60
Reinheit:
98.73
CAS Nummer:
[3053223-31-4]
Formel:
C33H27N5O3
Target-Kategorie:
ROR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
