Antitumor agent-169 (Compound B3) is a dual inhibitor PD-1/PD-L1 interaction and PARP7, with IC50s of 0.426 µM and 2.50 nM. Antitumor agent-169 exhibits an affinity to human PD-L1, with Ki of 20.2 nM. Antitumor agent-169 restores the T cell function, increases IFN-gamma secretion. Antitumor agent-169 inhibits cell viability of MDA-MB-231 and Jurkat T, exhibits antitumor efficacy against melanoma in mouse model and good pharmacokinetic characteristics[1].
Molekulargewicht:
1087.19
Formel:
C55H69F3N10O10
Target-Kategorie:
PARP,PD-1/PD-L1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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