Antitumor agent-170 (Compound C6) exhibits inhibitory activities against PD-1/PD-L1 interaction and PARP7, with IC50 of 0.342 µM and 7.05 nM. Antitumor agent-170 exhibits a high affinity to human PD-L1, with a Ki of 9.31 nM. Antitumor agent-170 restores the T cell function and increases IFN-gamma secretion. Antitumor agent-170 exhibits antitumor efficacy against melanoma in mouse models and good pharmacokinetic characteristics[1].
Molekulargewicht:
1168.70
Formel:
C59H69ClF3N11O9
Target-Kategorie:
PARP,PD-1/PD-L1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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