JI-101 (hydrochloride), CAS [[2514957-81-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: JI-101 (hydrochloride), CAS [[2514957-81-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-16265A
• Hersteller Artikelnummer: HY-16265A
• Alternativnummer: MCE-HY-16265A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

JI-101 hydrochloride is an orally active angiogenesis inhibitor and anticancer agent with 55% oral bioavailability in Sprague Dawley rats, high permeability, and no P-gp substrate activity[1][2].JI-101 hydrochloride modulates angiogenesis signaling pathways in tumor vessel beds, downregulates EphB4, targets EphB4, VEGFR-2, and PDGFR-beta, and inhibits multiple stages of tumor angiogenesis[1].JI-101 hydrochloride exerts activity against cancer cells and xenografts, exhibits mild to moderate inhibition of CYP3A4, and shows stability in pre-clinical and human liver microsomes[1][2].JI-101 hydrochloride undergoes rapid oral absorption in Sprague Dawley rats, has extensive tissue distribution with preferred lung uptake, and is excreted via bile with mono- and di-hydroxy metabolites, with feces as the primary elimination route[2].JI-101 hydrochloride can be used for the research of ovarian cancer and solid tumors[1][2].

Produkteigenschaften

• Molekulargewicht: 502.79
• CAS Nummer: [2514957-81-2]
• Formel: C22H21BrClN5O2
• Target-Kategorie: Ephrin Receptor,PDGFR,VEGFR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound