MK2-IN-6 (Compound 11) is a potent and selective irreversible MK2 inhibitor with an IC50 value of 2.3 nM. MK2-IN-6 inhibits MK2 kinase activity, achieving prolonged MK2 signaling suppression and reducing pathological inflammatory cytokines in macrophages. MK2-IN-6 inhibits the M2-like protumor phenotype of macrophages both in vitro and in vivo, which is proming for research of colorectal cancer[1].
Molekulargewicht:
442.39
Formel:
C22H17F3N4O3
Target-Kategorie:
MAPKAPK2 (MK2)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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