COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 µM, 95.58 µM and 58.82 µM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinsons disease (PD) symptoms in mice[1].
Molekulargewicht:
463.41
CAS Nummer:
[2987884-27-3]
Formel:
C24H18FN3O6
Target-Kategorie:
COMT,Monoamine Oxidase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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