hURAT1 inhibitor 1 (compound 27b) is an isomarine-based, orally active dual hURAT1/GLUT9 inhibitor with IC50s of 0.16 µM and 4.47 µM, respectively, and has anti-hyperuricemia effects. hURAT1 inhibitor 1 showed significant uric acid-lowering activity in a hyperuricemia mouse model (10 mg/kg dose). hURAT1 inhibitor 1 had no significant in vitro cytotoxicity or in vivo hepatotoxicity and showed good PK characteristics[1].
Molekulargewicht:
451.31
Formel:
C24H19BrO4
Target-Kategorie:
GLUT,URAT1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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