AURKA against 1 is an inhibitor of AURKA (IC50 less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3[1].
Molekulargewicht:
545.61
Formel:
C28H32FN9O2
Target-Kategorie:
Aurora Kinase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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