Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC50 for tubulin=2.40 µM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization[1].
Molekulargewicht:
504.66
Reinheit:
98.03
CAS Nummer:
[3072778-26-5]
Formel:
C25H32N2O5S2
Target-Kategorie:
Microtubule/Tubulin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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