TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRKWT, TRKG595R and TRKG667C, respectively. TRK-IN-2 shows antiproliferative activity with IC50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKAWT, Ba/F3-ETV6-TRKBWT, Ba/F3-LMNA-TRKG595R and Ba/F3-LMNA-TRKAG667C, respectively[1].
Molekulargewicht:
485.53
CAS Nummer:
[2991504-43-7]
Formel:
C27H25F2N7
Target-Kategorie:
Trk Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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