TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-alpha, IFN-alpha1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections[1].
Molekulargewicht:
411.54
Formel:
C22H33N7O
Target-Kategorie:
Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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