BuChE-IN-11 (Compound 3b-1) is an selective BuChE inhibitor with an IC50 of 0.44 µM for hBuChE. BuChE-IN-11 has high blood-brain barrier permeability and exhibits strong antioxidant activity due to its free radical scavenging properties. BuChE-IN-11 interacts with the choline binding site, acetyl binding site, and peripheral anionic site, exhibiting submicromolar BuChE inhibitory activity and preventing beta-amyloid (Abeta) self-aggregation. BuChE-IN-11 holds promise for research in the field of Alzheimers disease[1].
Molekulargewicht:
470.54
Formel:
C28H27FN4O2
Target-Kategorie:
Cholinesterase (ChE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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