Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase beta (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 µM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 µM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models[1].
Molekulargewicht:
373.37
Formel:
C19H18F3N5
Target-Kategorie:
PI4K,Potassium Channel
Anwendungsbeschreibung:
Reference compound
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