Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41412, which exhibits phosphodiesterase 4 (PDE4) inhibitory activity (IC50=1.2 µM). Talaroterphenyl A also exhibits anti-inflammatory and anti-fibrotic activities, significantly reducing the mRNA levels of pro-inflammatory cytokines IL-6, TNF-alpha, and IL-1beta[1].
Molekulargewicht:
364.39
Formel:
C22H20O5
Target-Kategorie:
Phosphodiesterase (PDE)
Anwendungsbeschreibung:
Natural Products
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