Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinsons Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable[1].
Molekulargewicht:
394.85
Formel:
C21H19ClN4O2
Target-Kategorie:
Nuclear Hormone Receptor 4A/NR4A
Anwendungsbeschreibung:
MCE Product type: Reference compound
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