PPA24 is a PP2A activator with a KD of 8.465 µM for PP2ACalpha. PPA24 induces cancer cell death via apoptosis. PP2ACalpha induces ROS generation and decreases the level of c-Myc expression. PPA24 can be used to study colorectal cancer (CRC), Folinic acid (HY-17556), 5-Fluorouracil (HY-90006), and Oxaliplatin (HY-17371) (FOLFOX)-resistant CRC, and melanoma cancer[1][2][3].
Molekulargewicht:
508.91
Reinheit:
98.09
CAS Nummer:
[3035032-77-7]
Formel:
C22H27BrClN5S
Target-Kategorie:
Apoptosis,c-Myc,ERK,GSK-3,Phosphatase,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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