PROTAC FGFR2 degrader 1, CAS [[3099123-99-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC FGFR2 degrader 1, CAS [[3099123-99-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-163985
• Hersteller Artikelnummer: HY-163985
• Alternativnummer: MCE-HY-163985-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC FGFR2 degrader 1 (compound N5) is a PROTAC that effectively targets FGFR2 with DC50 of 6.46 nM, the FGFR2 IC50 is 0.08 nM. PROTAC FGFR2 degrader 1 has anti-proliferative activity and highly selective, induces G0/G1 arrest of KATOIII and SNU16 cell cycle and inhibits apoptosis by reducing the activation of p-ERK and p-PLCgamma, the downstream proteins of FGFR2. PROTAC FGFR2 degrader 1 inhibits gastric cancer cells remained above 50% at a concentration of 0.17 nM. PROTAC FGFR2 degrader 1 potently inhibits the growth of SNU16 xenograft tumors in mouse model (Structure Note: Pink, FGFR2 activator: HY-18708, Blue, E3 ligase ligand: HY--10984, Black, linker: HY-163989, E3 ligase ligand + linker:HY-163986) [1].

Produkteigenschaften

• Molekulargewicht: 858.98
• CAS Nummer: [3099123-99-3]
• Formel: C46H54N10O7
• Target-Kategorie: Apoptosis,FGFR,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound