TAS-121, CAS [[1451370-01-6]] Preis auf Anfrage
Artikelnummer:
MCE-HY-164392
| Artikelname: |
TAS-121, CAS [[1451370-01-6]] Preis auf Anfrage |
| Artikelnummer: |
MCE-HY-164392 |
| Hersteller Artikelnummer: |
HY-164392 |
| Alternativnummer: |
MCE-HY-164392-1UNIT |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| TAS-121 is an orally active, selective, covalent, third-generation mutant EGFR-tyrosine kinase inhibitor (EGFR-TKI). TAS-121 inhibits the L858R mutation (IC50=1.7 nM), Ex19del mutation (IC50=2.7 nM), L858R/T790M mutation (IC50=0.56 nM) and Ex19del/T790M mutation (IC50=1.1 nM) and wild-type EGFR (IC50=8.2 nM). TAS-121 inhibits HER2 and HER4 with IC50s of 110 and 2.6 nM, respectively. TAS-121 inhibits phosphorylation of EGFR and its downstream signaling targets to block cell proliferation. TAS-121 induces apoptosis and displays antitumor activity in SW48 (EGFR G719S) and NCI-H1975 (EGFR L858R/T790M) xenograft models[1]. |
| Molekulargewicht: |
384.43 |
| CAS Nummer: |
[1451370-01-6] |
| Formel: |
C22H20N6O |
| Target-Kategorie: |
Apoptosis,EGFR |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound |
