QBS10072S (dihydrochloride), CAS [[1802735-31-4]]

Produktübersicht

• Artikelname: QBS10072S (dihydrochloride), CAS [[1802735-31-4]]
• Artikelnummer: MCE-HY-164401A
• Hersteller Artikelnummer: HY-164401A
• Alternativnummer: MCE-HY-164401A-50MG, MCE-HY-164401A-25MG, MCE-HY-164401A-10MG, MCE-HY-164401A-100MG, MCE-HY-164401A-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

QBS10072S dihydrochloride is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S dihydrochloride exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 µM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 µM). QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S dihydrochloride can be used for the research of glioblastoma and aggressive T-cell lymphoma[1][2].

Produkteigenschaften

• Molekulargewicht: 406.18
• CAS Nummer: [1802735-31-4]
• Formel: C15H24Cl4N2O2
• Target-Kategorie: DNA Alkylator/Crosslinker,DNA/RNA Synthesis,EAAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound