PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy[1].
Molekulargewicht:
392.45
CAS Nummer:
[1093793-11-3]
Formel:
C21H24N6O2
Target-Kategorie:
Checkpoint Kinase (Chk)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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