Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to beta-tubulin and promotes tubulin polymerization (EC50 = 0.9 µM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G2-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel (HY-B0015) sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel (HY-B0011) resistant solid tumors[1].
Molekulargewicht:
896.01
CAS Nummer:
[791635-59-1]
Formel:
C46H57NO15S
Target-Kategorie:
Apoptosis,Caspase,Microtubule/Tubulin
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
