NH2-NODAGA TFA is a NODAGA-type metal chelator that can bind to radionuclides to prepare radionuclide conjugates (RDCs). NH2-NODAGA TFA can react with diethyl squarate in 0.5M phosphate buffer (room temperature, 2 h, pH 7-7.5) to obtain NODAGA.SA. NODAGA.SA can target L-lysine urea-L-glutamate (KuE), which is a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can bind [68]Ga and can be used for PET examination of NMRInu/nu nude mice bearing LNCaP tumors.
Molekulargewicht:
531.48
CAS Nummer:
[3053227-80-5]
Formel:
C19H32F3N5O9
Target-Kategorie:
PSMA,Radionuclide-Drug Conjugates (RDCs)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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