CM-118 is a potent and selective c-Met and ALK inhibitor. CM-118 inhibits the HGF-induced c-Met phosphorylation. CM-118 inhibits phosphorylation of ALK, EML4-ALKv1, ALK F1174L, and EMl4-ALKv1 L1196M, with respective IC50 values 0.92, 1.25, 1.9, and 3.5 µM. CM-118 exhibits anticancer activity against cancers dependent on the c-Met or ALK oncogenic pathways[1].
Molekulargewicht:
452.27
CAS Nummer:
[1370652-56-4]
Formel:
C19H16Cl2FN5O3
Target-Kategorie:
Anaplastic lymphoma kinase (ALK),c-Met/HGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
