(E)-Dothiepin ((E)-Dosulepin,(E)-Dothep) hydrochloride is an antidepressant agent with sedative/anxiolytic activity. (E)-Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. (E)-Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. (E)-Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. (E)-Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain,idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
Molekulargewicht:
331.90
CAS Nummer:
[25627-36-5]
Formel:
C19H22ClNS
Target-Kategorie:
Histamine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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