AU-461 is an orally active and reversible inhibitor of the gastric H/K ATPase with IC50 values for rabbit-derived and pig-derived enzymes are 12.15 µM and 4.20 µM respectively. AU-461 competes with activated cationic K (K = 1.64 µM). AU-461 reduces both histamine-stimulated gastric acid secretion and basal gastric acid secretion in rats. AU-461 inhibits ulcer formation caused by ethanol or sodium hydroxide, and restores the plasma gastrin level to normal. AU-461 can be used for the study of peptic ulcers[1].
Molekulargewicht:
447.45
CAS Nummer:
[220854-06-8]
Formel:
C23H24F3N3O3
Target-Kategorie:
Na+/K+ ATPase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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