SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 µM and a Ki of 0.6 µM. SMI-4a also inhibits Pim-2 (IC50 of 100 µM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1].
Molekulargewicht:
273.23
Reinheit:
99.85
CAS Nummer:
[438190-29-5]
Formel:
C11H6F3NO2S
Target-Kategorie:
Pim
Anwendungsbeschreibung:
MCE Product type: Reference compound
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