ML314 is a potent, BBB-penetrant and beta-arrestin biased molecule agonist of NTR1 (EC50 = 1.9 µM). ML314 shows good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions[1][2].
Molekulargewicht:
420.50
Reinheit:
99.52
CAS Nummer:
[1448895-09-7]
Formel:
C24H28N4O3
Target-Kategorie:
GPR35 ,Neurotensin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
