RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits alpha-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 µM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1].
Molekulargewicht:
224.23
CAS Nummer:
[1807639-36-6]
Formel:
C10H8O4S
Target-Kategorie:
E1/E2/E3 Enzyme
Anwendungsbeschreibung:
MCE Product type: Reference compound
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