PT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC50=0.143 µM, JNK2: IC50=0.831 µM, JNK3: IC50=0.285 µM) and other kinases (SGK1: IC50=1.34 µM, SGK2: IC50=5.6 µM, SGK3: IC50=26.4 µM, ROCK2: IC50=34 µM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2 pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity[1][2].
Molekulargewicht:
429.64
Reinheit:
99.20
CAS Nummer:
[2059104-90-2]
Formel:
C23H31N3OS2
Target-Kategorie:
JNK,ROCK,SGK
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
