KW-2450 (free base), CAS [[904899-25-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: KW-2450 (free base), CAS [[904899-25-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-167854
• Hersteller Artikelnummer: HY-167854
• Alternativnummer: MCE-HY-167854-1MG,MCE-HY-167854-5MG,MCE-HY-167854-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

KW-2450 Free base is a potent multikinase inhibitor targeting Aurora A and B kinases, demonstrating significant antitumor activity against triple-negative breast cancer (TNBC). KW-2450 Free base effectively reduces cell viability, promotes apoptosis, and inhibits colony formation and mammosphere formation in TNBC cells. KW-2450 Free base significantly suppresses the growth of TNBC xenografts, leading to tetraploid accumulation followed by apoptosis or the survival of octaploid cells. KW-2450 Free base enhances the efficacy of combination therapy with the MEK inhibitor selumetinib, resulting in a synergistic antitumor effect in TNBC models. KW-2450 Free base also acts as an orally bioavailable inhibitor of IGF-1R and IR tyrosine kinases, contributing to its potential antineoplastic activity by inhibiting tumor cell proliferation and inducing apoptosis.

Produkteigenschaften

• Molekulargewicht: 515.63
• CAS Nummer: [904899-25-8]
• Formel: C28H29N5O3S
• Target-Kategorie: Apoptosis,Aurora Kinase,IGF-1R

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound