CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB)[1].
Molekulargewicht:
402.19
Formel:
C18H12Cl2F3NO2
Target-Kategorie:
Apoptosis,YAP
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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