NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC50=0.26 µM in THP-1 cells, IC50=0.21 µM in mouse bone marrow macrophages). NLRP3-IN-49 can directly bind to NLRP3 protein (Kd=1.05 µM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease[1].
Molekulargewicht:
491.40
Formel:
C22H23BrN2O4S
Target-Kategorie:
NOD-like Receptor (NLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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