TH023 is an inhibitor for the TLR4 signaling pathway, that targets especially the formation of TLR4 homodimer. TH023 inhibits secreted embryonic alkaline phosphatase in cell HEK-Blue hTLR4 with an IC50 of 0.354 µM, and inhibits the NO expression in RAW264.7 with an IC50 of 1.61µM. TH023 also inhibits the activation of NF-kappaB, reduces the nuclear translocation of NF-kappaB p65. TH023 exhibits anti-inflammatory efficacy in LPS (HY-D1056)-induced mouse acute sepsis model, and ameliorates the mouse lung injury[1].
Molekulargewicht:
430.88
Formel:
C22H21ClF2N4O
Target-Kategorie:
NF-kappaB,Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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