CL-13 is a butyrylcholinesterase (BChE) inhibitor, with an IC50 of 1.15 µM, and a selectivity index (SI) of 9.2 for acetylcholinesterase. CL-13 shows antioxidant activity in SH-SY5Y cells (DPPH EC50 = 47.01 µM) and has the ability to chelate metals involved in Abeta aggregation and/or oxidative stress, showing no neurotoxicity at 50 µM. CL-13 can reverse cognitive impairment caused by scopolamine (HY-N0296) without affecting the mices motor skills[1].
Molekulargewicht:
484.66
Formel:
C29H32N4OS
Target-Kategorie:
Amyloid-beta,Cholinesterase (ChE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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